How this calculator works
Louvet and colleagues derived Lille in severe alcohol-associated hepatitis treated with corticosteroids. The original model uses bilirubin evolution after seven days: baseline minus day-7 bilirubin. Renal insufficiency is set when baseline creatinine is above 1.3 mg/dL or known creatinine clearance is below 40 mL/min. This page uses PT in seconds, albumin in g/L and bilirubin in micromol/L. It is not a pre-treatment screen or an independent instruction to stop or start medicine. The result is an estimate for information only and is not medical advice.
Formula
R = 3.19 - 0.101 x age + 0.147 x albumin0 + 0.0165 x (bilirubin0 - bilirubin7) - 0.206 x renal indicator - 0.0065 x bilirubin0 - 0.0096 x PT. Lille = 1 / (1 + exp(R)).
Worked example
Age 50, albumin 30 g/L, bilirubin 200 to 100 micromol/L, PT 18 seconds and no renal insufficiency give R = 2.7272 and Lille approximately 0.0613873.
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Frequently asked questions
Can I use day 4 in this page?
No. This page labels and implements the original day-7 model. A day-4 approach needs its own validation and clinical protocol.
Why does falling bilirubin reduce the score?
The evolution term is baseline minus follow-up. Improvement raises R, which lowers the logistic score.
Does Lille replace specialist judgement?
No. It applies to a specific treated population, and treatment decisions require the full clinical picture.